AustralieFrV1, Main, Exploration, bibRecord, 003912

Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

Identifieur interne : 003912 ( Main/Exploration ); précédent : 003911; suivant : 003913

Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

Auteurs : Stéphanie Debette ; Carla A. Ibrahim Verbaas ; Jan Bressler ; Maaike Schuur ; Albert Smith ; Joshua C. Bis ; Gail Davies ; Christiane Wolf ; Vilmundur Gudnason ; Lori B. Chibnik ; Qiong Yang ; Anita L. Destefano ; Dominique J. F. De Quervain ; Velandai Srikanth ; Jari Lahti ; Hans J. Grabe ; Jennifer A. Smith ; Lutz Priebe ; Lei Yu ; Nazanin Karbalai ; Caroline Hayward ; James F. Wilson ; Harry Campbell ; Katja Petrovic ; Myriam Fornage ; Ganesh Chauhan ; Robin Yeo ; Ruth Boxall ; James Becker ; Oliver Stegle ; Karen A. Mather ; Vincent Chouraki ; Qi Sun ; Lynda M. Rose ; Susan Resnick ; Christopher Oldmeadow ; Mirna Kirin ; Alan F. Wright ; Maria K. Jonsdottir ; Rhoda Au ; Albert Becker ; Najaf Amin ; Mike A. Nalls ; Stephen T. Turner ; Sharon L. R. Kardia ; Ben Oostra ; Gwen Windham ; Laura H. Coker ; Wei Zhao ; David S. Knopman ; Gerardo Heiss ; Michael E. Griswold ; Rebecca F. Gottesman ; Veronique Vitart ; Nicholas D. Hastie ; Lina Zgaga ; Igor Rudan ; Ozren Polasek ; Elizabeth G. Holliday ; Peter Schofield ; Seung Hoan Choi ; Toshiko Tanaka ; Yang An ; Rodney T. Perry ; Richard E. Kennedy ; Michèle M. Sale ; Jing Wang ; Virginia G. Wadley ; David C. Liewald ; Paul M. Ridker ; Alan J. Gow ; Alison Pattie ; John M. Starr ; David Porteous ; Xuan Liu ; Russell Thomson ; Nicola J. Armstrong ; Gudny Eiriksdottir ; Arezoo A. Assareh ; Nicole A. Kochan ; Elisabeth Widen ; Aarno Palotie ; Yi-Chen Hsieh ; Johan G. Eriksson ; Christian Vogler ; John C. Van Swieten ; Joshua M. Shulman ; Alexa Beiser ; Jerome Rotter ; Carsten O. Schmidt ; Wolfgang Hoffmann ; Markus M. Nöthen ; Luigi Ferrucci ; John Attia ; Andre G. Uitterlinden ; Philippe Amouyel ; Jean-François Dartigues ; Hélène Amieva ; Katri R Ikkönen ; Melissa Garcia ; Philip A. Wolf ; Albert Hofman ; W. T. Longstreth ; Bruce M. Psaty ; Eric Boerwinkle ; Philip L. Dejager ; Perminder S. Sachdev ; Reinhold Schmidt ; Monique M. B. Breteler ; Alexander Teumer ; Oscar L. Lopez ; Sven Cichon ; Daniel I. Chasman ; Francine Grodstein ; Bertram Müller-Myhsok ; Christophe Tzourio ; Andreas Papassotiropoulos ; David A. Bennett ; Arfan M. Ikram ; Ian J. Deary ; Cornelia M. Van Duijn ; Lenore Launer ; Annette L. Fitzpatrick ; Sudha Seshadri ; Thomas H. Mosley

Source :

Biological psychiatry [ 0006-3223 ] ; 2014.

RBID : PMC:4513651

Descripteurs français

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging (genetics), Apolipoproteins E (genetics), Claudin-5 (genetics), Cohort Studies, Female, Genome-Wide Association Study, Genotype, Humans, Male, Memory Disorders (genetics), Middle Aged, Polymorphism, Single Nucleotide (genetics), Proteins (genetics), Proteoglycans (genetics), Regression Analysis, Sulfotransferases (genetics), Verbal Learning (physiology).
MESH :
- chemical , genetics : Apolipoproteins E, Claudin-5, Proteins, Proteoglycans, Sulfotransferases.
- genetics : Aging, Memory Disorders, Polymorphism, Single Nucleotide.
- physiology : Verbal Learning.
- Aged, Aged, 80 and over, Cohort Studies, Female, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Regression Analysis.

Abstract

BACKGROUND

Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting.

METHODS

We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia-and stroke-free individuals of European descent, aged ≥45 years. Replication of suggestive associations (p < 5 × 10⁻⁶) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults.

RESULTS

rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 × 10⁻¹⁰) and replication cohorts (p = 5.65 × 10⁻⁸). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 × 10⁻⁸, and rs6813517 [SPOCK3], p = 2.58 × 10⁻⁸) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism.

CONCLUSIONS

This largest study to date exploring the genetics of memory function in ~ 40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513651

DOI: 10.1016/j.biopsych.2014.08.027
PubMed: 25648963
PubMed Central: 4513651

Affiliations:

Le document en format XML

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<author><name sortKey="Assareh, Arezoo A" sort="Assareh, Arezoo A" uniqKey="Assareh A" first="Arezoo A." last="Assareh">Arezoo A. Assareh</name>
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<author><name sortKey="Vogler, Christian" sort="Vogler, Christian" uniqKey="Vogler C" first="Christian" last="Vogler">Christian Vogler</name>
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<author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
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</author>
<author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
</author>
<author><name sortKey="Rotter, Jerome" sort="Rotter, Jerome" uniqKey="Rotter J" first="Jerome" last="Rotter">Jerome Rotter</name>
</author>
<author><name sortKey="Schmidt, Carsten O" sort="Schmidt, Carsten O" uniqKey="Schmidt C" first="Carsten O." last="Schmidt">Carsten O. Schmidt</name>
</author>
<author><name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name>
</author>
<author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
</author>
<author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
</author>
<author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
</author>
<author><name sortKey="Amieva, Helene" sort="Amieva, Helene" uniqKey="Amieva H" first="Hélène" last="Amieva">Hélène Amieva</name>
</author>
<author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name>
</author>
<author><name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name>
</author>
<author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
</author>
<author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name>
</author>
<author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
</author>
<author><name sortKey="Dejager, Philip L" sort="Dejager, Philip L" uniqKey="Dejager P" first="Philip L." last="Dejager">Philip L. Dejager</name>
</author>
<author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
</author>
<author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
</author>
<author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
</author>
<author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
</author>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
</author>
<author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name>
</author>
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<author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
</author>
<author><name sortKey="Papassotiropoulos, Andreas" sort="Papassotiropoulos, Andreas" uniqKey="Papassotiropoulos A" first="Andreas" last="Papassotiropoulos">Andreas Papassotiropoulos</name>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
</author>
<author><name sortKey="Ikram, Arfan M" sort="Ikram, Arfan M" uniqKey="Ikram A" first="Arfan M." last="Ikram">Arfan M. Ikram</name>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
</author>
<author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
</author>
<author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
</author>
</analytic>
<series><title level="j">Biological psychiatry</title>
<idno type="ISSN">0006-3223</idno>
<idno type="eISSN">1873-2402</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging (genetics)</term>
<term>Apolipoproteins E (genetics)</term>
<term>Claudin-5 (genetics)</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Memory Disorders (genetics)</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Proteins (genetics)</term>
<term>Proteoglycans (genetics)</term>
<term>Regression Analysis</term>
<term>Sulfotransferases (genetics)</term>
<term>Verbal Learning (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Apolipoprotéines E (génétique)</term>
<term>Apprentissage verbal (physiologie)</term>
<term>Claudine-5 (génétique)</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Protéines (génétique)</term>
<term>Protéoglycanes (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Sulfotransferases (génétique)</term>
<term>Troubles de la mémoire (génétique)</term>
<term>Vieillissement (génétique)</term>
<term>Étude d'association pangénomique</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
<term>Claudin-5</term>
<term>Proteins</term>
<term>Proteoglycans</term>
<term>Sulfotransferases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term>
<term>Memory Disorders</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéines E</term>
<term>Claudine-5</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines</term>
<term>Protéoglycanes</term>
<term>Sulfotransferases</term>
<term>Troubles de la mémoire</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apprentissage verbal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Verbal Learning</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Regression Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Étude d'association pangénomique</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>BACKGROUND</title>
<p id="P1">Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting.</p>
</sec>
<sec id="S2"><title>METHODS</title>
<p id="P2">We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia-and stroke-free individuals of European descent, aged ≥45 years. Replication of suggestive associations (<italic>p</italic>
 < 5 × 10<sup>−6</sup>
) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">rs4420638, near <italic>APOE</italic>
, was associated with poorer delayed recall performance in discovery (<italic>p</italic>
 = 5.57 × 10<sup>−10</sup>
) and replication cohorts (<italic>p</italic>
 = 5.65 × 10<sup>−8</sup>
). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [<italic>HS3ST4</italic>
]<italic>, p</italic>
 = 3.11 × 10<sup>−8</sup>
, and rs6813517 [<italic>SPOCK3</italic>
], <italic>p</italic>
 = 2.58 × 10<sup>−8</sup>
) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with <italic>WDR48</italic>
 and <italic>CLDN5</italic>
, both related to ubiquitin metabolism.</p>
</sec>
<sec id="S4"><title>CONCLUSIONS</title>
<p id="P4">This largest study to date exploring the genetics of memory function in ~ 40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Amieva, Helene" sort="Amieva, Helene" uniqKey="Amieva H" first="Hélène" last="Amieva">Hélène Amieva</name>
<name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="An, Yang" sort="An, Yang" uniqKey="An Y" first="Yang" last="An">Yang An</name>
<name sortKey="Armstrong, Nicola J" sort="Armstrong, Nicola J" uniqKey="Armstrong N" first="Nicola J." last="Armstrong">Nicola J. Armstrong</name>
<name sortKey="Assareh, Arezoo A" sort="Assareh, Arezoo A" uniqKey="Assareh A" first="Arezoo A." last="Assareh">Arezoo A. Assareh</name>
<name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name>
<name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name>
<name sortKey="Becker, Albert" sort="Becker, Albert" uniqKey="Becker A" first="Albert" last="Becker">Albert Becker</name>
<name sortKey="Becker, James" sort="Becker, James" uniqKey="Becker J" first="James" last="Becker">James Becker</name>
<name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<name sortKey="Boxall, Ruth" sort="Boxall, Ruth" uniqKey="Boxall R" first="Ruth" last="Boxall">Ruth Boxall</name>
<name sortKey="Bressler, Jan" sort="Bressler, Jan" uniqKey="Bressler J" first="Jan" last="Bressler">Jan Bressler</name>
<name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name>
<name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name>
<name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung Hoan" last="Choi">Seung Hoan Choi</name>
<name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name>
<name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name>
<name sortKey="De Quervain, Dominique J F" sort="De Quervain, Dominique J F" uniqKey="De Quervain D" first="Dominique J. F." last="De Quervain">Dominique J. F. De Quervain</name>
<name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name>
<name sortKey="Dejager, Philip L" sort="Dejager, Philip L" uniqKey="Dejager P" first="Philip L." last="Dejager">Philip L. Dejager</name>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name>
<name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<name sortKey="Garcia, Melissa" sort="Garcia, Melissa" uniqKey="Garcia M" first="Melissa" last="Garcia">Melissa Garcia</name>
<name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F." last="Gottesman">Rebecca F. Gottesman</name>
<name sortKey="Gow, Alan J" sort="Gow, Alan J" uniqKey="Gow A" first="Alan J." last="Gow">Alan J. Gow</name>
<name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name>
<name sortKey="Griswold, Michael E" sort="Griswold, Michael E" uniqKey="Griswold M" first="Michael E." last="Griswold">Michael E. Griswold</name>
<name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<name sortKey="Hastie, Nicholas D" sort="Hastie, Nicholas D" uniqKey="Hastie N" first="Nicholas D." last="Hastie">Nicholas D. Hastie</name>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<name sortKey="Heiss, Gerardo" sort="Heiss, Gerardo" uniqKey="Heiss G" first="Gerardo" last="Heiss">Gerardo Heiss</name>
<name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<name sortKey="Hsieh, Yi Chen" sort="Hsieh, Yi Chen" uniqKey="Hsieh Y" first="Yi-Chen" last="Hsieh">Yi-Chen Hsieh</name>
<name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim Verbaas">Carla A. Ibrahim Verbaas</name>
<name sortKey="Ikram, Arfan M" sort="Ikram, Arfan M" uniqKey="Ikram A" first="Arfan M." last="Ikram">Arfan M. Ikram</name>
<name sortKey="Jonsdottir, Maria K" sort="Jonsdottir, Maria K" uniqKey="Jonsdottir M" first="Maria K." last="Jonsdottir">Maria K. Jonsdottir</name>
<name sortKey="Karbalai, Nazanin" sort="Karbalai, Nazanin" uniqKey="Karbalai N" first="Nazanin" last="Karbalai">Nazanin Karbalai</name>
<name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<name sortKey="Kennedy, Richard E" sort="Kennedy, Richard E" uniqKey="Kennedy R" first="Richard E." last="Kennedy">Richard E. Kennedy</name>
<name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name>
<name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name>
<name sortKey="Kochan, Nicole A" sort="Kochan, Nicole A" uniqKey="Kochan N" first="Nicole A." last="Kochan">Nicole A. Kochan</name>
<name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
<name sortKey="Liewald, David C" sort="Liewald, David C" uniqKey="Liewald D" first="David C." last="Liewald">David C. Liewald</name>
<name sortKey="Liu, Xuan" sort="Liu, Xuan" uniqKey="Liu X" first="Xuan" last="Liu">Xuan Liu</name>
<name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. Mather</name>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A." last="Nalls">Mike A. Nalls</name>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<name sortKey="Oldmeadow, Christopher" sort="Oldmeadow, Christopher" uniqKey="Oldmeadow C" first="Christopher" last="Oldmeadow">Christopher Oldmeadow</name>
<name sortKey="Oostra, Ben" sort="Oostra, Ben" uniqKey="Oostra B" first="Ben" last="Oostra">Ben Oostra</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Papassotiropoulos, Andreas" sort="Papassotiropoulos, Andreas" uniqKey="Papassotiropoulos A" first="Andreas" last="Papassotiropoulos">Andreas Papassotiropoulos</name>
<name sortKey="Pattie, Alison" sort="Pattie, Alison" uniqKey="Pattie A" first="Alison" last="Pattie">Alison Pattie</name>
<name sortKey="Perry, Rodney T" sort="Perry, Rodney T" uniqKey="Perry R" first="Rodney T." last="Perry">Rodney T. Perry</name>
<name sortKey="Petrovic, Katja" sort="Petrovic, Katja" uniqKey="Petrovic K" first="Katja" last="Petrovic">Katja Petrovic</name>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<name sortKey="Porteous, David" sort="Porteous, David" uniqKey="Porteous D" first="David" last="Porteous">David Porteous</name>
<name sortKey="Priebe, Lutz" sort="Priebe, Lutz" uniqKey="Priebe L" first="Lutz" last="Priebe">Lutz Priebe</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name>
<name sortKey="Resnick, Susan" sort="Resnick, Susan" uniqKey="Resnick S" first="Susan" last="Resnick">Susan Resnick</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name>
<name sortKey="Rotter, Jerome" sort="Rotter, Jerome" uniqKey="Rotter J" first="Jerome" last="Rotter">Jerome Rotter</name>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
<name sortKey="Sale, Michele M" sort="Sale, Michele M" uniqKey="Sale M" first="Michèle M." last="Sale">Michèle M. Sale</name>
<name sortKey="Schmidt, Carsten O" sort="Schmidt, Carsten O" uniqKey="Schmidt C" first="Carsten O." last="Schmidt">Carsten O. Schmidt</name>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<name sortKey="Schofield, Peter" sort="Schofield, Peter" uniqKey="Schofield P" first="Peter" last="Schofield">Peter Schofield</name>
<name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<name sortKey="Smith, Albert" sort="Smith, Albert" uniqKey="Smith A" first="Albert" last="Smith">Albert Smith</name>
<name sortKey="Smith, Jennifer A" sort="Smith, Jennifer A" uniqKey="Smith J" first="Jennifer A." last="Smith">Jennifer A. Smith</name>
<name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name>
<name sortKey="Stegle, Oliver" sort="Stegle, Oliver" uniqKey="Stegle O" first="Oliver" last="Stegle">Oliver Stegle</name>
<name sortKey="Sun, Qi" sort="Sun, Qi" uniqKey="Sun Q" first="Qi" last="Sun">Qi Sun</name>
<name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
<name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<name sortKey="Vogler, Christian" sort="Vogler, Christian" uniqKey="Vogler C" first="Christian" last="Vogler">Christian Vogler</name>
<name sortKey="Wadley, Virginia G" sort="Wadley, Virginia G" uniqKey="Wadley V" first="Virginia G." last="Wadley">Virginia G. Wadley</name>
<name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name>
<name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<name sortKey="Windham, Gwen" sort="Windham, Gwen" uniqKey="Windham G" first="Gwen" last="Windham">Gwen Windham</name>
<name sortKey="Wolf, Christiane" sort="Wolf, Christiane" uniqKey="Wolf C" first="Christiane" last="Wolf">Christiane Wolf</name>
<name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<name sortKey="Yeo, Robin" sort="Yeo, Robin" uniqKey="Yeo R" first="Robin" last="Yeo">Robin Yeo</name>
<name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
<name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name>
<name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name>
</noCountry>
</tree>
</affiliations>
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   |texte=   Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
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Serveur d'exploration sur les relations entre la France et l'Australie

Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

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	Serveur d'exploration sur les relations entre la France et l'Australie
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